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Letrozole, Femara oral steroid hormone
Letrozole, Femara oral steroid hormone Letrozole, Femara oral steroid hormone
  • Letrozole, Femara oral steroid hormone

  • Category : oral steroid hormone
  • CAS No : 112809-51-5
  • Molecular formula : C17H11N5
  • Molecular weight : 285.303 g/mol
  • Assay : 99%
  • Supply ability : 100kg/week
  • Delivery time : 3~5 days

Details

Product name: letrozole white powder

Trade name: Femara

CAS NO: 112809-51-5

letrozole Content: 99%

Molecular Formula: C17H11N5 letrozole

Molar mass: 285.303 g/mol

Quality standard: USP29

Apperance: off-white crystal

Packing: as your require

Storage: shading, confined preservation.

Letrozole is an oral non-steroidal inhibitor for the treatment of hormonally-responsive breast cancer after surgery.

letrozole prevents the aromatase from producing estrogens by competitive, reversible binding to the heme of its cytochrome p450 unit, the action is specific,and letrozol does not reduce production of mineralo-or corticosteroids.

In cotrast, tamoxifen interferes with estrogen receptor, tamoxifen is also used to treat hormonally-responsive breast cancer. However, letrozol is effective only in post-menopausal women, in whom estrogen is produced predominantly in the main source od estrogen is from the ovaries not the peripheral tissues, and letrozol is ineffective.


Uses

FDA-approved use

Femara 2.5 mg oral tablet

Letrozole is approved by the United States Food and Drug Administration (FDA) for the treatment of local or metastatic breast cancer that is hormone receptor positive or has an unknown receptor status in postmenopausal women.

Off-label uses

Letrozole has been used for ovarian stimulation by fertility doctors since 2001 because it has fewer side-effects than clomiphene (Clomid) and less chance of multiple gestation. A study of 150 babies following treatment with letrozole or letrozole and gonadotropins presented at the American Society of Reproductive Medicine 2005 Conference found no difference in overall abnormalities but did find a significantly higher rate of locomotor and cardiac abnormalities among the group having taken letrozole compared to natural conception. A larger, follow-up study with 911 babies compared those born following treatment with letrozole to those born following treatment with clomiphene. That study also found no significant difference in the rate of overall abnormalities, but found that congenital cardiac anomalies was significantly higher in the clomiphene group compared to the letrozole group. Despite this, India banned the usage of letrozole in 2011, citing potential risks to infants. In 2012, an Indian parliamentary committee said that the drug controller office colluded with letrozole's makers to approve the drug for infertility in India and also stated that letrozole's use for infertility was illegal worldwide; however, such off-label uses are legal in many countries such as the US and UK.

The anti-estrogen action of letrozole has been shown to be useful in pretreatment for termination of pregnancy, in combination with misoprostol. It can be used in place of mifepristone, which is expensive and unavailable in many countries.

Letrozole is sometimes used as a treatment for gynecomastia, although it is probably most effective at this if caught in an early stage (such as in users of anabolic steroids).

Some studies have shown that letrozole can be used to promote spermatogenesis in male patients suffering from nonobstructive azoospermia.

Letrozole has also been shown to delay the fusing of the growth plates in mice. When used in combination with growth hormone, letrozole has been shown effective in one adolescent boy with a short stature.

Letrozole has also been used to treat endometriosis.


How letrozole works

Letrozole lowers the levels of the female sex hormone oestrogen in the body. Oestrogen stimulates some breast cancers to grow. These breast cancers are called hormone sensitive or hormone receptor positive. Letrozole can stop or slow the growth of these cancers. It can also reduce the chance of a breast cancer coming back after surgery.

Letrozole only works in women who have had their menopause. It is a type of drug called an aromatase inhibitor. After the menopause, women don’t produce oestrogen from their ovaries. But they still produce a small amount by using an enzyme called aromatase which turns other sex hormones called androgens into oestrogen. This change happens mainly in fatty tissue, muscle and the skin. Aromatase inhibitors block aromatase so that it can’t change the androgen into oestrogen.


How you have letrozole

You take letrozole as a tablet, once a day. It is best to take the tablets at the same time each day. You can take them with or without food.

It is very important that you take tablets according to the instructions your doctor or pharmacist gave you. You should take the right dose, not more or less. And never stop taking a cancer drug without talking to your specialist first.

If you accidentally take too much Femara, contact a doctor or hospital straight away. You may need medical treatment. 

If you forget to take a dose and it is almost time for your next dose (for example, within 2 or 3 hours), skip the dose you missed and take your next dose when it is due. Otherwise, take the dose as soon as you remember, and then take the next dose at the normal time. Don't take a double dose.


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