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Dextromethorphan Hydrobromide DXM or DM
  • Dextromethorphan Hydrobromide DXM or DM

  • Category : Testosterone steroid
  • CAS No : 125-71-3
  • Molecular formula : C18H25NO
  • Molecular weight : 271.40 g/mol
  • Assay : 99%
  • Supply ability : 20kg/month
  • Delivery time : 3~5 days

Details

Dextromethorphan Hydrobromide

Dextromethorphan (DXM or DM) is an antitussive

Systematic (IUPAC) name:

(+)-3-methoxy-17-methyl-(9α,13α,14α)-morphinanDextromethorphan.svg

Trade names:

Robitussin, Delsym, DM, DexAlone, Duract

CAS number:125-71-3

Formula:C18H25NO 

Mol. mass:271.40 g/mol

Test Items

Specification

Test Results

Appearance

white or almost white crystalline powder, slightly smelly

white crystalline powder

Melting point

123~127°C

123~125°C

Specific Rotation

+28°~+30°

+29°

Acidity(PH)

5.2~6.5

5.8~6.2

Water

4.0%~5.5%

5.0%

Residue On Ignition

Not more than 0.1%

Conforms

N.N - dimethylaniline

Comply with the standard

Conforms

Phenolic Compounds

Comply with the standard

Conforms

Related Substance

Comply with the standard

Conforms

Assay

Between99.0~102.0%

99.53%


Dextromethorphan (DXM or DM) is a drug of the morphinan class with sedative, dissociative, and stimulant properties (at higher doses). It is a cough suppressant in many over-the-counter cold and cough medicines including generic labels and store brands, Benylin DM, Mucinex DM, Camydex-20 tablets, Robitussin, NyQuil, Dimetapp, Vicks, Coricidin, Delsym, TheraFlu, Cheracol D, and others. Dextromethorphan has also found numerous other uses in medicine, ranging from pain relief (as either the primary analgesic, or an opioid potentiator) over psychological applications to the treatment of addiction. It is sold in syrup, tablet, spray, and lozenge forms. In its pure form, dextromethorphan occurs as a white powder.

Dextromethorphan (DXM) is a safe and effective ingredient found in more than 100 over-the-counter (OTC) cough and cold medicines. First approved by the U.S. Food and Drug Administration (FDA) in the 1950s, it is an effective, non-narcotic cough suppressant that works by raising the coughing threshold in the brain. It has no pain-relieving properties and is not addictive.

While millions of Americans use DXM safely each year to relieve cough symptoms due to the common cold or flu, data released in December 2015 by the National Institute on Drug Abuse (NIDA) annual Monitoring the Future survey shows that approximately 3 percent of teens admit to abusing cough medicines to get high.


Medical use

Cough suppression

The primary use of dextromethorphan is as a cough suppressant, for the temporary relief of cough caused by minor throat and bronchial irritation (such as commonly accompanies the flu and common cold), as well as those resulting from inhaled particle irritants.

Recreational use

Chemistry

Dextromethorphan is the dextrorotatory enantiomer of levomethorphan, which is the methyl ether of levorphanol, both opioid analgesics. It is named according to IUPAC rules as (+)-3-methoxy-17-methyl-9α,13α,14α-morphinan. As its pure form, dextromethorphan occurs as an odorless, opalescent white powder. It is freely soluble in chloroform and insoluble in water; the hydrobromide salt is water-soluble up to 1.5g/100 mL at 25 °C. extromethorphan is commonly available as the monohydrated hydrobromide salt, however some newer extended-release formulations contain dextromethorphan bound to an ion-exchange resin based on polystyrene sulfonic acid. Dextromethorphan's specific rotation in water is +27.6° (20 °C, Sodium D-line)


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